GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes. Belongs to the POU transcription factor family. Class-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16 C1.3|16 37.25 cM
Cellular Component:  nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  adenohypophysis development; B cell differentiation; cell fate specification; determination of adult lifespan; negative regulation of transcription by RNA polymerase II; pituitary gland development; positive regulation of cell proliferation; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription, DNA-templated; somatotropin secreting cell development; somatotropin secreting cell differentiation
Reference #:  Q00286 (UniProtKB)
Alt. Names/Synonyms: 9430075J19Rik; A230098E07Rik; brain-2 class III POU-domain protein; brain-specific homeobox/POU domain protein 2; Brn-2; Brn2; dwarf; GHF-1; Growth hormone factor 1; Hmp; Hmp1; nervous system-specific octamer-binding transcription factor N-Oct-3; oct-7; octamer-binding protein 7; octamer-binding transcription factor 7; OTF-7; Otf7; OTTMUSP00000005047; Pit; PIT-1; Pit1; Pit1-rs1; pituitary specific transcription factor 1, related sequence 1; Pituitary-specific positive transcription factor 1; POU domain, class 1, transcription factor 1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); POU domain, class 3, transcription factor 2; Pou1f1; Pou3f2
Gene Symbols: Pou1f1
Molecular weight: 32,885 Da
Basal Isoelectric point: 8.37  Predict pI for various phosphorylation states
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GHF-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein