|
galectin-3
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. Note: This description may include information from UniProtKB.
|
| Protein type: Cell surface; Extracellular matrix; Motility/polarity/chemotaxis |
|
Cellular Component:
cytoplasm; extracellular region; spliceosomal complex
|
|
Molecular Function:
carbohydrate binding; IgE binding
|
|
Biological Process:
cell differentiation; innate immune response; mRNA processing; RNA splicing
|
|
Reference #:
P38486
(UniProtKB)
|
|
Alt. Names/Synonyms: 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; Gal-3; Galactose-specific lectin 3; galectin 3; Galectin-3; IgE-binding protein; Laminin-binding protein; LEG3; LEG3_CANFA; LGALS3; Mac-2 antigen
|
|
Gene Symbols: LGALS3
|
|
Molecular weight:
30,330 Da
|
|
Basal Isoelectric point:
7.78
Predict pI for various phosphorylation states
|
