IP3R1 Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. Widely expressed. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q41
Cellular Component:  calcineurin complex; cytoplasm; cytoplasmic vesicle membrane; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; GABA-ergic synapse; integral component of endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle; membrane raft; neuronal cell body; nuclear envelope; nuclear inner membrane; nucleolus; perinuclear region of cytoplasm; plasma membrane; platelet dense granule membrane; platelet dense tubular network; postsynapse; postsynaptic density; presynapse; protein-containing complex; sarcoplasmic reticulum; Schaffer collateral - CA1 synapse; secretory granule membrane; smooth endoplasmic reticulum membrane; synaptic membrane; transport vesicle membrane
Molecular Function:  calcium channel inhibitor activity; calcium ion binding; calcium-release channel activity; identical protein binding; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; phosphatidylinositol binding; protein binding; protein C-terminus binding; protein phosphatase binding; protein-containing complex binding
Biological Process:  calcium ion transmembrane transport; calcium ion transport; cellular response to cAMP; cellular response to hypoxia; dendrite development; endoplasmic reticulum calcium ion homeostasis; epithelial fluid transport; inositol phosphate-mediated signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; liver regeneration; negative regulation of calcium-mediated signaling; negative regulation of neuron death; positive regulation of apoptotic process; positive regulation of calcium ion transport; positive regulation of cytosolic calcium ion concentration; positive regulation of hepatocyte proliferation; positive regulation of neuron projection development; post-embryonic development; protein homotetramerization; regulation of postsynaptic cytosolic calcium ion concentration; release of sequestered calcium ion into cytosol; response to hypoxia; voluntary musculoskeletal movement
Reference #:  P29994 (UniProtKB)
Alt. Names/Synonyms: I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; Insp3r; InsP3R1; IP-3-R; IP3 receptor; IP3 receptor isoform 1; IP3R 1; IP3R1; Itpr1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene Symbols: Itpr1
Molecular weight: 313,264 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene