PDE1A Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. Several tissues, including brain, kidney, testes and heart. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 2|2 C3
Cellular Component:  cytoplasm; neuronal cell body; nucleus
Molecular Function:  3',5'-cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity
Biological Process:  cGMP catabolic process; regulation of smooth muscle cell apoptotic process; regulation of smooth muscle cell proliferation; signal transduction
Reference #:  Q61481 (UniProtKB)
Alt. Names/Synonyms: 61 kDa Cam-PDE; AI987702; AW125737; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; MGC116577; OTTMUSP00000014309; OTTMUSP00000014311; OTTMUSP00000014325; OTTMUSP00000014326; Pde1a; phosphodiesterase 1A, calmodulin-dependent
Gene Symbols: Pde1a
Molecular weight: 62,347 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
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PDE1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene