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PDE1A
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. Several tissues, including brain, kidney, testes and heart. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase |
| Chromosomal Location of Human Ortholog: 2|2 C3 |
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Cellular Component:
cytoplasm; neuronal cell body; nucleus
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Molecular Function:
3',5'-cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity
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Biological Process:
cGMP catabolic process; regulation of smooth muscle cell apoptotic process; regulation of smooth muscle cell proliferation; signal transduction
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Reference #:
Q61481
(UniProtKB)
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Alt. Names/Synonyms: 61 kDa Cam-PDE; AI987702; AW125737; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; MGC116577; OTTMUSP00000014309; OTTMUSP00000014311; OTTMUSP00000014325; OTTMUSP00000014326; Pde1a; phosphodiesterase 1A, calmodulin-dependent
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Gene Symbols: Pde1a
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Molecular weight:
62,347 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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