PDE1A Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component:  cytosol; nucleus
Molecular Function:  calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; metal ion binding
Biological Process:  cGMP catabolic process; G protein-coupled receptor signaling pathway; regulation of smooth muscle cell apoptotic process; regulation of smooth muscle cell proliferation
Reference #:  P54750 (UniProtKB)
Alt. Names/Synonyms: 3',5' cyclic nucleotide phosphodiesterase; 61 kDa Cam-PDE; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-dependent phosphodiesterase; Cam-PDE 1A; hCam-1; HCAM1; HSPDE1A; MGC26303; PDE1A; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A
Gene Symbols: PDE1A
Molecular weight: 61,252 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
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PDE1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein