Kv3.4 This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 3 F2.3|3 46.83 cM
Cellular Component:  axon; axon terminus; calyx of Held; cell surface; dendrite; dendrite membrane; endoplasmic reticulum; glutamatergic synapse; glycinergic synapse; Golgi apparatus; integral component of membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuromuscular junction; neuronal cell body; neuronal cell body membrane; plasma membrane; postsynapse; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity
Biological Process:  ion transport; negative regulation of neuronal action potential; negative regulation of sensory perception of pain; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; regulation of neurotransmitter secretion; transmembrane transport
Reference #:  Q8R1C0 (UniProtKB)
Alt. Names/Synonyms: AI850292; Kcnc4; Kcr2-; Kcr2-4; KSHIIIC; Kv3.; Kv3.4; potassium voltage gated channel, Shaw-related subfamily, member 4; Potassium voltage-gated channel subfamily C member 4; Voltage-gated potassium channel subunit Kv3.4
Gene Symbols: Kcnc4
Molecular weight: 68,655 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene