eIF2-alpha Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-alpha family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Cellular Component: 
Reference #:  P83268 (UniProtKB)
Alt. Names/Synonyms: eIF-2-alpha; eIF-2A; eIF-2alpha; EIF2A; eIF2S1; eukaryotic translation initiation factor 2 alpha subunit; Eukaryotic translation initiation factor 2 subunit 1; IF2A
Gene Symbols: EIF2S1
Molecular weight: 5,974 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
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eIF2-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene