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TPH2
an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase |
| Chromosomal Location of Human Ortholog: 12q21.1 |
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Cellular Component:
cytosol; neuron projection
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Molecular Function:
iron ion binding; tryptophan 5-monooxygenase activity
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Biological Process:
aromatic amino acid family metabolic process; cellular response to lithium ion; circadian rhythm; response to activity; response to calcium ion; response to estrogen; response to glucocorticoid stimulus; response to nutrient levels; serotonin biosynthetic process
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Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder
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Reference #:
Q8IWU9
(UniProtKB)
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Alt. Names/Synonyms: ADHD7; FLJ37295; MGC138871; MGC138872; Neuronal tryptophan hydroxylase; NTPH; TPH2; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2
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Gene Symbols: TPH2
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Molecular weight:
56,057 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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