TPH2 an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q21.1
Cellular Component:  cytosol; neuron projection
Molecular Function:  iron ion binding; tryptophan 5-monooxygenase activity
Biological Process:  aromatic amino acid family metabolic process; cellular response to lithium ion; circadian rhythm; response to activity; response to calcium ion; response to estrogen; response to glucocorticoid stimulus; response to nutrient levels; serotonin biosynthetic process
Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder
Reference #:  Q8IWU9 (UniProtKB)
Alt. Names/Synonyms: ADHD7; FLJ37295; MGC138871; MGC138872; Neuronal tryptophan hydroxylase; NTPH; TPH2; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2
Gene Symbols: TPH2
Molecular weight: 56,057 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TPH2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene