IkB-alpha a regulatory protein that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of Human Ortholog: 12|12 C1
Cellular Component:  cytoplasm; cytosol; nucleus; plasma membrane; protein-containing complex
Molecular Function:  enzyme binding; heat shock protein binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; protein-containing complex binding; ubiquitin protein ligase binding
Biological Process:  cellular response to cytokine stimulus; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cellular protein metabolic process; positive regulation of cholesterol efflux; positive regulation of inflammatory response; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein import into nucleus; regulation of cell proliferation; regulation of gene expression; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9Z1E3 (UniProtKB)
Alt. Names/Synonyms: AI462015; I(Kappa)B(alpha); I-kappa-B-alpha; I-kappaBalpha; IkappaBalpha; IkB-alpha; Ikba; NF-kappa-B inhibitor alpha; Nfk; Nfkbi; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Symbols: Nfkbia
Molecular weight: 35,071 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IkB-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene