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HMGA1
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Belongs to the HMGA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 17 A3.3|17 14.5 cM |
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Cellular Component:
nucleus; RNA polymerase II transcription factor complex; senescence-associated heterochromatin focus
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Molecular Function:
5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; chromatin binding; DNA binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-binding transcription activator activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; enzyme binding; nuclear receptor transcription coactivator activity; peroxisome proliferator activated receptor binding; retinoic acid receptor binding; retinoid X receptor binding; structural constituent of chromatin; transcription coactivator activity; transcription factor binding
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Biological Process:
base-excision repair; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; spermatogenesis
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Reference #:
P17095
(UniProtKB)
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Alt. Names/Synonyms: AL023995; high mobility group AT-hook 1; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; Hmg; HMG-I(Y; HMG-I(Y); Hmga; Hmga1; Hmga1a; Hmga1b; Hmgi; HMGI(Y; Hmgiy; Hmgy; MGC102580
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Gene Symbols: Hmga1
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Molecular weight:
11,614 Da
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Basal Isoelectric point:
10.31
Predict pI for various phosphorylation states
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