|
HMGA1
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Belongs to the HMGA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 17 A3.3|17 14.5 cM |
|
Cellular Component:
male germ cell nucleus; nucleus; RNA polymerase II transcription regulator complex; senescence-associated heterochromatin focus
|
|
Molecular Function:
5'-deoxyribose-5-phosphate lyase activity; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA binding, bending; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding; minor groove of adenine-thymine-rich DNA binding; molecular adaptor activity; molecular function activator activity; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; peroxisome proliferator activated receptor binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; structural constituent of chromatin; transcription coactivator activity; transcription coregulator activity; transcription coregulator binding
|
|
Biological Process:
base-excision repair; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; oncogene-induced cell senescence; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; spermatogenesis
|
|
Reference #:
P17095
(UniProtKB)
|
|
Alt. Names/Synonyms: AL023995; high mobility group AT-hook 1; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; Hmg; HMG-I(Y; HMG-I(Y); Hmga; Hmga1; Hmga1a; Hmga1b; Hmgi; HMGI(Y; Hmgiy; Hmgy; MGC102580
|
|
Gene Symbols: Hmga1
|
|
Molecular weight:
11,614 Da
|
|
Basal Isoelectric point:
10.31
Predict pI for various phosphorylation states
|
