HMGA1 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Belongs to the HMGA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 17 A3.3|17 14.5 cM
Cellular Component:  male germ cell nucleus; nucleus; RNA polymerase II transcription regulator complex; senescence-associated heterochromatin focus
Molecular Function:  5'-deoxyribose-5-phosphate lyase activity; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA binding, bending; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding; minor groove of adenine-thymine-rich DNA binding; molecular adaptor activity; molecular function activator activity; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; peroxisome proliferator activated receptor binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; structural constituent of chromatin; transcription coactivator activity; transcription coregulator activity; transcription coregulator binding
Biological Process:  base-excision repair; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; oncogene-induced cell senescence; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; spermatogenesis
Reference #:  P17095 (UniProtKB)
Alt. Names/Synonyms: AL023995; high mobility group AT-hook 1; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; Hmg; HMG-I(Y; HMG-I(Y); Hmga; Hmga1; Hmga1a; Hmga1b; Hmgi; HMGI(Y; Hmgiy; Hmgy; MGC102580
Gene Symbols: Hmga1
Molecular weight: 11,614 Da
Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein