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TPH2
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Brain specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 10|10 D2 |
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Cellular Component:
neuron projection
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Molecular Function:
iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; tryptophan 5-monooxygenase activity
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Biological Process:
aromatic amino acid family metabolic process; serotonin biosynthetic process; serotonin biosynthetic process from tryptophan
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Reference #:
Q8CGV2
(UniProtKB)
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Alt. Names/Synonyms: AU043594; MGC159133; Neuronal tryptophan hydroxylase; Ntph; OTTMUSP00000022885; Tph2; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2
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Gene Symbols: Tph2
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Molecular weight:
55,859 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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