TPH2 Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Brain specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase
Chromosomal Location of mouse Ortholog: 10|10 D2
Cellular Component:  neuron projection
Molecular Function:  iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; tryptophan 5-monooxygenase activity
Biological Process:  aromatic amino acid family metabolic process; serotonin biosynthetic process; serotonin biosynthetic process from tryptophan
Reference #:  Q8CGV2 (UniProtKB)
Alt. Names/Synonyms: AU043594; MGC159133; Neuronal tryptophan hydroxylase; Ntph; OTTMUSP00000022885; Tph2; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2
Gene Symbols: Tph2
Molecular weight: 55,859 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TPH2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene