HMGA1 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Belongs to the HMGA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 6p21.31
Cellular Component:  cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; senescence-associated heterochromatin focus; transcription regulator complex
Molecular Function:  chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA binding, bending; enzyme binding; minor groove of adenine-thymine-rich DNA binding; molecular adaptor activity; molecular function activator activity; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; peroxisome proliferator activated receptor binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; structural constituent of chromatin; transcription coactivator activity; transcription coregulator activity; transcription coregulator binding
Biological Process:  DNA unwinding involved in DNA replication; DNA-templated transcription; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; nucleosome disassembly; oncogene-induced cell senescence; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
Reference #:  P17096 (UniProtKB)
Alt. Names/Synonyms: high mobility group AT-hook 1; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; High mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; HMG-I(Y); HMG-R; HMGA1; HMGA1A; HMGIY; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
Gene Symbols: HMGA1
Molecular weight: 11,676 Da
Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HMGA1

Protein Structure Not Found.


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