HMGA1
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Belongs to the HMGA family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of human Ortholog: 6p21.31 |
Cellular Component:
cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; senescence-associated heterochromatin focus; transcription regulator complex
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Molecular Function:
chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA binding, bending; enzyme binding; minor groove of adenine-thymine-rich DNA binding; molecular adaptor activity; molecular function activator activity; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; peroxisome proliferator activated receptor binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; structural constituent of chromatin; transcription coactivator activity; transcription coregulator activity; transcription coregulator binding
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Biological Process:
DNA unwinding involved in DNA replication; DNA-templated transcription; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; nucleosome disassembly; oncogene-induced cell senescence; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
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Reference #:
P17096
(UniProtKB)
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Alt. Names/Synonyms: high mobility group AT-hook 1; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; High mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; HMG-I(Y); HMG-R; HMGA1; HMGA1A; HMGIY; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
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Gene Symbols: HMGA1
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Molecular weight:
11,676 Da
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Basal Isoelectric point:
10.31
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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