ADCY6 Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  cell projection; cilium; endosome; integral component of membrane; integral component of plasma membrane; intrinsic component of plasma membrane; membrane; membrane raft; microvillus membrane; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; lyase activity; metal ion binding; nucleotide binding; phosphorus-oxygen lyase activity; protein kinase binding; protein kinase C binding; scaffold protein binding; signaling receptor binding; SNARE binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to catecholamine stimulus; cellular response to forskolin; cellular response to prostaglandin E stimulus; cellular response to vasopressin; cyclic nucleotide biosynthetic process; dopamine receptor signaling pathway; intracellular signal transduction; maintenance of protein location in plasma membrane; negative regulation of neuron projection development; negative regulation of urine volume; regulation of blood vessel diameter; renal water homeostasis
Reference #:  Q01341 (UniProtKB)
Alt. Names/Synonyms: AC6; Adcy6; adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; mKIAA0422
Gene Symbols: Adcy6
Molecular weight: 130,319 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene