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ADCY6
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of human Ortholog: 12q13.12 |
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Cellular Component:
cilium; membrane; plasma membrane; stereocilium
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Molecular Function:
adenylate cyclase activity; ATP binding; metal ion binding; protein binding; protein kinase binding; protein kinase C binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; cAMP biosynthetic process; cellular response to catecholamine stimulus; cellular response to forskolin; cellular response to prostaglandin E stimulus; cellular response to vasopressin; dopamine receptor signaling pathway; intracellular signal transduction; negative regulation of neuron projection development; negative regulation of urine volume; renal water homeostasis
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Disease: Lethal Congenital Contracture Syndrome 8
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Reference #:
O43306
(UniProtKB)
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Alt. Names/Synonyms: AC6; ADCY6; adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; KIAA0422; LCCS8
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Gene Symbols: ADCY6
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Molecular weight:
130,615 Da
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Basal Isoelectric point:
8.56
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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NF-kB Signaling
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Parkinson's Disease
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