Kir5.1 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 17q24.3
Cellular Component:  basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  inward rectifier potassium channel activity
Biological Process:  potassium ion import across plasma membrane; potassium ion transport; regulation of monoatomic ion transmembrane transport
Disease: Hypokalemic Tubulopathy And Deafness
Reference #:  Q9NPI9 (UniProtKB)
Alt. Names/Synonyms: BIR9; Inward rectifier K(+) channel Kir5.1; inward rectifier K+ channel KIR5.1; Inward rectifier potassium channel 16; IRK16; KCJ16; KCNJ16; KIR5.1; MGC33717; Potassium channel, inwardly rectifying subfamily J member 16; potassium inwardly rectifying channel subfamily J member 16; potassium inwardly-rectifying channel, subfamily J, member 16; potassium voltage-gated channel subfamily J member 16
Gene Symbols: KCNJ16
Molecular weight: 47,949 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene