RARA Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression. Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells. In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in monocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 17q21.2
Cellular Component:  actin cytoskeleton; chromatin; cytoplasm; cytosol; dendrite; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  alpha-actinin binding; chromatin binding; chromatin DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; enzyme binding; histone deacetylase binding; mRNA 5'-UTR binding; mRNA regulatory element binding translation repressor activity; nuclear receptor activity; protein binding; protein domain specific binding; protein kinase A binding; protein kinase B binding; retinoic acid binding; retinoic acid-responsive element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription coactivator binding; zinc ion binding
Biological Process:  apoptotic cell clearance; cell differentiation; cellular response to estrogen stimulus; cellular response to lipopolysaccharide; cellular response to retinoic acid; chondroblast differentiation; embryonic camera-type eye development; face development; female pregnancy; germ cell development; glandular epithelial cell development; growth plate cartilage development; hippocampus development; hormone-mediated signaling pathway; limb development; liver development; mRNA transcription by RNA polymerase II; multicellular organism growth; negative regulation of cartilage development; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of granulocyte differentiation; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; negative regulation of translation; negative regulation of tumor necrosis factor production; negative regulation of type II interferon production; neural tube closure; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription by RNA polymerase II; prostate gland development; protein phosphorylation; regulation of apoptotic process; regulation of hematopoietic progenitor cell differentiation; regulation of myelination; regulation of synaptic plasticity; response to cytokine; response to estradiol; response to ethanol; response to retinoic acid; response to vitamin A; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; trachea cartilage development; ureteric bud development; ventricular cardiac muscle cell differentiation
Disease: Acute Promyelocytic Leukemia
Reference #:  P10276 (UniProtKB)
Alt. Names/Synonyms: NR1B1; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR-alpha; RARA; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; Retinoic acid receptor alpha; retinoic acid receptor, alpha; Retinoic acid receptor, alpha polypeptide
Gene Symbols: RARA
Molecular weight: 50,771 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein