PKLR Plays a key role in glycolysis. Belongs to the pyruvate kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; potassium ion binding; pyruvate kinase activity
Biological Process:  ATP biosynthetic process; carbohydrate metabolic process; cellular response to epinephrine stimulus; cellular response to insulin stimulus; glycolytic process; pyruvate biosynthetic process; response to ATP; response to cAMP; response to glucose; response to heat; response to hypoxia; response to lithium ion; response to metal ion; response to nutrient; response to other organism
Reference #:  P12928 (UniProtKB)
Alt. Names/Synonyms: KPYR; L-PK; PK1; PKL; Pklg; Pklr; Pyruvate kinase isozymes R/L; Pyruvate kinase PKLR; pyruvate kinase, liver and RBC; pyruvate kinase, liver and red blood cell
Gene Symbols: Pklr
Molecular weight: 62,200 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene