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PIGR
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of human Ortholog: 1q32.1 |
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Cellular Component:
azurophil granule membrane; extracellular space; plasma membrane; receptor complex; secretory IgA immunoglobulin complex
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Molecular Function:
polymeric immunoglobulin receptor activity; transmembrane signaling receptor activity
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Biological Process:
detection of chemical stimulus involved in sensory perception of bitter taste; epidermal growth factor receptor signaling pathway; Fc receptor signaling pathway; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; receptor clustering
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Disease: Iga Nephropathy, Susceptibility To, 1
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Reference #:
P01833
(UniProtKB)
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Alt. Names/Synonyms: FLJ22667; hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; MGC125361; MGC125362; PIGR; Poly-Ig receptor; Polymeric immunoglobulin receptor; Secretory component
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Gene Symbols: PIGR
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Molecular weight:
83,284 Da
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Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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