Mena
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Belongs to the Ena/VASP family. Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 1q42.12 |
Cellular Component:
cell junction; cytoskeleton; cytosol; filopodium; focal adhesion; lamellipodium; plasma membrane; synapse
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Molecular Function:
actin binding; profilin binding; protein binding; SH3 domain binding; WW domain binding
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Biological Process:
actin polymerization or depolymerization; actin polymerization-dependent cell motility; axon guidance
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Reference #:
Q8N8S7
(UniProtKB)
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Alt. Names/Synonyms: ENA; enabled homolog; enabled homolog (Drosophila); ENAH; ENAH actin regulator; mammalian enabled variant 11a; mammalian enabled variant pan; MENA; NDPP1; Protein enabled homolog
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Gene Symbols: ENAH
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Molecular weight:
66,510 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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