LGI1 Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component:  cell junction; extracellular region; extracellular space; glutamatergic synapse; membrane; synaptic cleft
Molecular Function:  protein binding; signaling receptor binding
Biological Process:  axon guidance; nervous system development; neuron projection development; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of cell growth; positive regulation of synaptic transmission; protein homooligomerization
Disease: Epilepsy, Familial Temporal Lobe, 1
Reference #:  O95970 (UniProtKB)
Alt. Names/Synonyms: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; Epitempin-1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; Leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1; LGI1
Gene Symbols: LGI1
Molecular weight: 63,818 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene