Mena iso3 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Required for the actin-based mobility of Listeria monocytogenes. Homotetramer. Interacts with APBB1IP, APBB1, PFN1 and ROBO4. Isoforms, containing the polyproline-rich regions with PPLP motifs, bind the WW domain of APBB1IP. Isoforms, containing the PPSY motif, bind, in vitro, to the WW2 and WW3 domains of NEDD4 and to the WW1 domain of YAP1. Binds the SH3 domain of BAIAP2-alpha but only after the autoinhibitory region of BAIAP2-alpha has been blocked by interaction with CDC42. Interacts, via the EVH1/WH1 domain, with the Pro-rich domains from VCL, ZYX and Listeria monocytogenes actA and with TES (via LIM domains). The TES LIM domain and the Pro-rich domains from VCL or ZYX compete for the same binding site. Interaction with ZYX is important for targeting ENAH to focal adhesions and enhances production of actin-rich structures at the apical surface of cells. Interacts, through the Pro-rich region, with the C-terminal SH3 domain of DNMPB. Binds GPHN. Interacts with FAT1 (via EVH1 domains). Heterotrimer with TES and ACTL7A. Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1 H5|1 84.93 cM
Cellular Component:  actin cytoskeleton; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; lamellipodium; plasma membrane; stress fiber; synapse
Molecular Function:  actin binding; profilin binding; protein binding; SH3 domain binding; WW domain binding
Biological Process:  actin cytoskeleton organization; actin filament organization; actin polymerization or depolymerization; actin polymerization-dependent cell motility; axon guidance; cell differentiation; cellular response to leukemia inhibitory factor; multicellular organism development; nervous system development; neural tube closure
Reference #:  Q03173-3 (UniProtKB)
Alt. Names/Synonyms: AI464316; AW045240; enabled homolog (Drosophila); Enah; Mena; NDPP-1; Ndpp1; NPC derived proline rich protein 1; NPC-derived proline-rich protein 1; Protein enabled homolog; WBP8
Gene Symbols: Enah
Molecular weight: 59,643 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Mena iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene