OBFC2A Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding
Chromosomal Location of Human Ortholog: 2q32.3
Cellular Component:  cytosol; nuclear chromosome, telomeric region; nucleoplasm; nucleus; SOSS complex
Molecular Function:  protein binding; RNA binding; single-stranded DNA binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to ionizing radiation; snRNA transcription by RNA polymerase II
Reference #:  Q96AH0 (UniProtKB)
Alt. Names/Synonyms: DKFZp667M1322; FLJ13624; FLJ22833; hSSB2; MGC111163; NABP1; nucleic acid binding protein 1; Nucleic acid-binding protein 1; OBFC2A; oligonucleotide/oligosaccharide-binding fold containing 2A; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSB2; SOSS complex subunit B2; SOSS-B2; SSB2
Gene Symbols: NABP1
Molecular weight: 22,423 Da
Basal Isoelectric point: 9.63  Predict pI for various phosphorylation states
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OBFC2A

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene