MAN2B1 Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. Belongs to the glycosyl hydrolase 38 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - other glycan degradation; Hydrolase
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component:  azurophil granule lumen; extracellular region; extracellular space; lysosomal lumen
Molecular Function:  carbohydrate binding; metal ion binding
Biological Process:  cellular protein modification process; neutrophil degranulation; oligosaccharide catabolic process
Disease: Mannosidosis, Alpha B, Lysosomal
Reference #:  O00754 (UniProtKB)
Alt. Names/Synonyms: LAMAN; Lysosomal acid alpha-mannosidase; Lysosomal alpha-mannosidase; Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide; MA2B1; MAN2B1; MANB; Mannosidase alpha class 2B member 1; Mannosidase alpha-B; mannosidase, alpha B, lysosomal; mannosidase, alpha, class 2B, member 1
Gene Symbols: MAN2B1
Molecular weight: 113,744 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein