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BRIP1
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Belongs to the DEAD box helicase family. DEAH subfamily. Ubiquitously expressed, with highest levels in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.13; Helicase; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 11|11 C |
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Cellular Component:
BRCA1-B complex; cytoplasm; nuclear membrane; nucleoplasm; nucleus
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Molecular Function:
4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; chromatin binding; DNA binding; DNA helicase activity; helicase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; iron-sulfur cluster binding; metal ion binding; nucleic acid binding; nucleotide binding; RNA helicase activity
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Biological Process:
chiasma assembly; DNA damage response; DNA repair; double-strand break repair involved in meiotic recombination; homologous chromosome pairing at meiosis; homologous recombination; male gonad development; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; negative regulation of cell population proliferation; negative regulation of gene expression; nucleobase-containing compound metabolic process; nucleotide-excision repair; regulation of transcription by RNA polymerase II; seminiferous tubule development; spermatid development; spermatogenesis; spermatogonial cell division
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Reference #:
Q5SXJ3
(UniProtKB)
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Alt. Names/Synonyms: 3110009N10Rik; 8030460J03Rik; ATP-dependent RNA helicase BRIP1; BACH; Bach1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; Brip1; FACJ; FANCJ; Fanconi anemia group J protein homolog; OF; OTTMUSP00000001009; Protein FACJ
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Gene Symbols: Brip1
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Molecular weight:
131,360 Da
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Basal Isoelectric point:
7.47
Predict pI for various phosphorylation states
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