RNF123 Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 9|9 F1
Cellular Component:  cytoplasm; cytosol; nuclear membrane
Molecular Function:  metal ion binding; transferase activity; ubiquitin-protein transferase activity
Biological Process:  proteolysis involved in cellular protein catabolic process
Reference #:  Q5XPI3 (UniProtKB)
Alt. Names/Synonyms: BC003945; E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; Kpc1; RING finger protein 123; RN123; Rnf123; ubiquitin ligase
Gene Symbols: Rnf123
Molecular weight: 148,652 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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RNF123

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein