Plasminogen Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Belongs to the peptidase S1 family. Plasminogen subfamily. Present in plasma and many other extracellular fluids. It is synthesized in the liver. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.7; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17 A1|17 8.5 cM
Cellular Component:  cell surface; extracellular region; extracellular space; extrinsic component of external side of plasma membrane; extrinsic component of plasma membrane; glutamatergic synapse; intracellular membrane-bounded organelle; other organism cell membrane; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  apolipoprotein binding; chaperone binding; endopeptidase activity; enzyme binding; hydrolase activity; kinase binding; peptidase activity; proteasome core complex binding; protein antigen binding; protein domain specific binding; serine-type endopeptidase activity; serine-type peptidase activity; signaling receptor binding
Biological Process:  blood coagulation; extracellular matrix disassembly; fibrinolysis; hemostasis; interaction with symbiont; interaction with symbiont via secreted substance involved in symbiotic interaction; labyrinthine layer blood vessel development; modification by host of symbiont morphology or physiology via secreted substance; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis; proteolysis involved in cellular protein catabolic process; tissue regeneration; tissue remodeling; trans-synaptic signaling by BDNF, modulating synaptic transmission; trophoblast giant cell differentiation
Reference #:  P20918 (UniProtKB)
Alt. Names/Synonyms: Activation peptide; AI649309; Angiostatin; Pg; Plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B; Plasminogen; Plg; PLMN
Gene Symbols: Plg
Molecular weight: 90,808 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
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Plasminogen

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene