SEL1L Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. Belongs to the sel-1 family. Highly expressed in pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of human Ortholog: 14q31.1
Cellular Component:  Derlin-1 retrotranslocation complex; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; Hrd1p ubiquitin ligase complex; Hrd1p ubiquitin ligase ERAD-L complex; integral component of membrane
Molecular Function:  protein binding
Biological Process:  endoplasmic reticulum mannose trimming; ERAD pathway; Notch signaling pathway; protein secretion; protein stabilization; retrograde protein transport, ER to cytosol; transmembrane transport; triglyceride metabolic process; ubiquitin-dependent ERAD pathway
Reference #:  Q9UBV2 (UniProtKB)
Alt. Names/Synonyms: Hrd3; IBD2; PRO1063; Protein sel-1 homolog 1; SE1L1; sel-1 (suppressor of lin-12, C.elegans)-like; sel-1 suppressor of lin-12-like (C. elegans); sel-1 suppressor of lin-12-like 1; Sel-1L; SEL1-LIKE; SEL1L; SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; SEL1L, ERAD E3 ligase adaptor subunit; SEL1L1; Suppressor of lin 12 (sel-1), C. elegans, homolog of; Suppressor of lin-12-like protein 1; TSA305
Gene Symbols: SEL1L
Molecular weight: 88,755 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB