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SEL1L
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. Belongs to the sel-1 family. Highly expressed in pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 14q31.1 |
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Cellular Component:
Derlin-1 retrotranslocation complex; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; Hrd1p ubiquitin ligase complex; Hrd1p ubiquitin ligase ERAD-L complex; integral component of membrane
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Molecular Function:
protein binding
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Biological Process:
endoplasmic reticulum mannose trimming; ERAD pathway; Notch signaling pathway; protein secretion; protein stabilization; retrograde protein transport, ER to cytosol; transmembrane transport; triglyceride metabolic process; ubiquitin-dependent ERAD pathway
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Reference #:
Q9UBV2
(UniProtKB)
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Alt. Names/Synonyms: Hrd3; IBD2; PRO1063; Protein sel-1 homolog 1; SE1L1; sel-1 (suppressor of lin-12, C.elegans)-like; sel-1 suppressor of lin-12-like (C. elegans); sel-1 suppressor of lin-12-like 1; Sel-1L; SEL1-LIKE; SEL1L; SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; SEL1L, ERAD E3 ligase adaptor subunit; SEL1L1; Suppressor of lin 12 (sel-1), C. elegans, homolog of; Suppressor of lin-12-like protein 1; TSA305
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Gene Symbols: SEL1L
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Molecular weight:
88,755 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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