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RNF186
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 1p36.13 |
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Cellular Component:
endoplasmic reticulum membrane
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Molecular Function:
metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein K29-linked ubiquitination; protein K63-linked ubiquitination; protein localization to mitochondrion
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Reference #:
Q9NXI6
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF186; FLJ20225; RING finger protein 186; RN186; RNF186; RP11-91K11.1
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Gene Symbols: RNF186
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Molecular weight:
24,145 Da
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Basal Isoelectric point:
7.02
Predict pI for various phosphorylation states
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