RNF186 E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 1p36.13
Cellular Component:  endoplasmic reticulum membrane
Molecular Function:  metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein K29-linked ubiquitination; protein K63-linked ubiquitination; protein localization to mitochondrion
Reference #:  Q9NXI6 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF186; FLJ20225; RING finger protein 186; RN186; RNF186; RP11-91K11.1
Gene Symbols: RNF186
Molecular weight: 24,145 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene