IL1A Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component:  cytosol; extracellular region; extracellular space
Molecular Function:  copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding
Biological Process:  apoptotic process; cellular response to heat; connective tissue replacement involved in inflammatory response wound healing; cytokine-mediated signaling pathway; ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; fever generation; immune response; interleukin-1-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cytokine secretion; positive regulation of gene expression; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic nuclear division; positive regulation of protein secretion; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; regulation of signaling receptor activity; response to copper ion
Reference #:  P01583 (UniProtKB)
Alt. Names/Synonyms: Hematopoietin-1; IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1; interleukin 1 alpha; interleukin 1, alpha; Interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
Gene Symbols: IL1A
Molecular weight: 30,607 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene