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IL1A
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
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| Protein type: Cytokine; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q14.1 |
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Cellular Component:
cell surface; cytosol; extracellular region; extracellular space; nucleus
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Molecular Function:
copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding
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Biological Process:
apoptotic process; cellular response to heat; cellular response to lipopolysaccharide; connective tissue replacement involved in inflammatory response wound healing; cytokine-mediated signaling pathway; ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; fever generation; heart development; immune response; inflammatory response; intracellular sodium ion homeostasis; keratinization; negative regulation of cell population proliferation; negative regulation of establishment of Sertoli cell barrier; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cytokine production; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of immature T cell proliferation in thymus; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of mitotic nuclear division; positive regulation of neutrophil migration; positive regulation of prostaglandin secretion; positive regulation of protein secretion; positive regulation of steroid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial growth factor production; regulation of actin cytoskeleton organization; regulation of nitric-oxide synthase activity; response to copper ion; response to gamma radiation; response to hypoxia; response to L-ascorbic acid; response to organonitrogen compound; response to ozone; spermatogenesis
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Reference #:
P01583
(UniProtKB)
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Alt. Names/Synonyms: Hematopoietin-1; IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1; interleukin 1 alpha; interleukin 1, alpha; Interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
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Gene Symbols: IL1A
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Molecular weight:
30,607 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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