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AI428936
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. Belongs to the nesprin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 19q13.12 |
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Cellular Component:
meiotic nuclear membrane microtubule tethering complex; nuclear outer membrane
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Molecular Function:
protein binding
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Biological Process:
establishment of epithelial cell apical/basal polarity
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Disease: Deafness, Autosomal Recessive 76
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Reference #:
Q8N205
(UniProtKB)
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Alt. Names/Synonyms: AI428936; C19orf46; chromosome 19 open reading frame 46; deafness, autosomal recessive 76; DFNB76; FLJ36445; KASH domain-containing protein 4; KASH4; Nesp4; Nesprin-4; Nuclear envelope spectrin repeat protein 4; spectrin repeat containing nuclear envelope family member 4; SYNE4
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Gene Symbols: SYNE4
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Molecular weight:
43,512 Da
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Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
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