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TRDMT1
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.204; Methyltransferase; Methyltransferase, tRNA |
| Chromosomal Location of human Ortholog: 10p13 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
RNA binding; tRNA (cytosine-5-)-methyltransferase activity; tRNA methyltransferase activity
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Biological Process:
response to amphetamine; tRNA methylation; tRNA modification; tRNA stabilization
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Reference #:
O14717
(UniProtKB)
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Alt. Names/Synonyms: DMNT2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA (cytosine-5-)-methyltransferase 2; DNA cytosine-5 methyltransferase 2; DNA methyltransferase homolog HsaIIP; DNA methyltransferase-2; DNA MTase homolog HsaIIP; DNMT2; M.HsaIIP; MHSAIIP; PuMet; RNMT1; TRDMT; TRDMT1; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase; tRNA aspartic acid methyltransferase 1
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Gene Symbols: TRDMT1
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Molecular weight:
44,597 Da
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Basal Isoelectric point:
5.78
Predict pI for various phosphorylation states
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