TMPO May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95. Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. Belongs to the LEM family. Expressed in many tissues. Most abundant in adult thymus and fetal liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral
Chromosomal Location of human Ortholog: 12q23.1
Cellular Component:  chromatin; nuclear envelope; nucleus
Molecular Function:  DNA binding; lamin binding; protein binding
Reference #:  P42167 (UniProtKB)
Alt. Names/Synonyms: CMD1T; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoforms beta/gamma; LAP2; LAP2B; LEM domain containing 4; LEMD4; MGC61508; PRO0868; Splenin; Thymopentin; Thymopoietin; Thymopoietin, isoforms beta/gamma; thymopoietin-related peptide; Thymopoietin-related peptide isoforms beta/gamma; TMPO; TP; TP alpha; TP beta/gamma; TP5; TPRP isoforms beta/gamma
Gene Symbols: TMPO
Molecular weight: 50,670 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein