GCGR G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 17q25.3
Cellular Component:  endosome; membrane; plasma membrane
Molecular Function:  G protein-coupled peptide receptor activity; glucagon receptor activity; peptide hormone binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cellular response to glucagon stimulus; cellular response to starvation; exocytosis; generation of precursor metabolites and energy; glucose homeostasis; hormone-mediated signaling pathway; positive regulation of gene expression; regulation of blood pressure; regulation of glycogen metabolic process; response to nutrient; response to starvation
Disease: Mahvash Disease
Reference #:  P47871 (UniProtKB)
Alt. Names/Synonyms: FLJ97182; GCGR; GGR; GL-R; GLR; Glucagon receptor; MGC138246
Gene Symbols: GCGR
Molecular weight: 54,009 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene