TMPO May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95. Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. Belongs to the LEM family. Expressed in many tissues. Most abundant in adult thymus and fetal liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10 C2|10 45.66 cM
Cellular Component:  chromatin; chromosome; integral component of membrane; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; nucleus
Molecular Function:  DNA binding; identical protein binding; protein binding
Biological Process:  regulation of transcription, DNA-templated
Reference #:  Q61029 (UniProtKB)
Alt. Names/Synonyms: 5630400D24Rik; AI195756; AI606875; AW214352; AW547477; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma; LAP2; thymopoietin; Tmpo; TP
Gene Symbols: Tmpo
Molecular weight: 50,373 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
Select Structure to View Below

TMPO

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein