calsequestrin 1 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity. Belongs to the calsequestrin family. Expressed in myoblasts (at protein level). Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Mitochondrial
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component:  endoplasmic reticulum; Golgi apparatus; mitochondrial matrix; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; T-tubule; terminal cisterna lumen
Molecular Function:  calcium ion binding; identical protein binding; protein binding
Biological Process:  endoplasmic reticulum organization; ion transmembrane transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of store-operated calcium channel activity; protein polymerization; regulation of cardiac conduction; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; regulation of store-operated calcium entry; response to denervation involved in regulation of muscle adaptation; response to heat; response to organic substance; sarcomere organization; skeletal muscle tissue development
Disease: Myopathy, Vacuolar, With Casq1 Aggregates
Reference #:  P31415 (UniProtKB)
Alt. Names/Synonyms: Calmitin; calmitine; calsequestrin 1 (fast-twitch, skeletal muscle); Calsequestrin, skeletal muscle isoform; Calsequestrin-1; CASQ; CASQ1; PDIB1
Gene Symbols: CASQ1
Molecular weight: 45,160 Da
Basal Isoelectric point: 4.03  Predict pI for various phosphorylation states
Select Structure to View Below

calsequestrin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein