A3GALT2 Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Belongs to the glycosyltransferase 6 family. Expressed in thymus and monocyte derived dendritic cells. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.87; Transferase
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component:  Golgi apparatus; integral component of membrane; membrane; vesicle
Molecular Function:  alpha-1,3-galactosyltransferase activity; metal ion binding; N-acetyllactosaminide 3-alpha-galactosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups
Biological Process:  carbohydrate metabolic process; cellular response to manganese ion; glycosphingolipid biosynthetic process; lipid glycosylation
Reference #:  Q3V1N9 (UniProtKB)
Alt. Names/Synonyms: A3galt2; A3LT2; alpha 1,3-galactosyltransferase 2; alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase); Alpha-1,3-galactosyltransferase 2; galactosyltransferase; Gm433; iGb; iGb3; iGb3 synthase; Igb3s; Isoglobotriaosylceramide synthase
Gene Symbols: A3galt2
Molecular weight: 42,649 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Select Structure to View Below

A3GALT2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene