PSMG2 Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. Belongs to the PSMG2 family. Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 18p11.21
Cellular Component:  nucleus
Molecular Function:  protein binding
Biological Process:  mitotic spindle assembly checkpoint; negative regulation of apoptotic process; proteasome assembly
Reference #:  Q969U7 (UniProtKB)
Alt. Names/Synonyms: CD40 ligand-activated specific transcript 3; CLAST3; HCCA3; HDCMC29P; hepatocellular carcinoma susceptibility protein; Hepatocellular carcinoma-susceptibility protein 3; HSPC260; HsT1707; likely ortholog of mouse CD40 ligand-activated specific transcript 3 (Clast3); MDS003; MGC15092; PAC-2; PAC2; proteasome (prosome, macropain) assembly chaperone 2; proteasome assembling chaperone 2; Proteasome assembly chaperone 2; PSMG2; TNFSF5IP1; Tumor necrosis factor superfamily member 5-induced protein 1; tumor necrosis factor superfamily, member 5-induced protein 1; x 003 protein
Gene Symbols: PSMG2
Molecular weight: 29,396 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB