calsequestrin 2 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Belongs to the calsequestrin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding
Chromosomal Location of mouse Ortholog: 3|3 F2.2
Cellular Component:  cytoplasm; junctional membrane complex; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; Z disc
Molecular Function:  calcium ion binding; calcium-dependent protein binding; metal ion binding; protein homodimerization activity; protein kinase C binding
Biological Process:  cardiac muscle contraction; cellular response to caffeine; negative regulation of potassium ion transmembrane transporter activity; negative regulation of potassium ion transport; negative regulation of ryanodine-sensitive calcium-release channel activity; protein polymerization; regulation of cardiac muscle cell contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell communication by electrical coupling; regulation of heart rate; regulation of membrane repolarization; regulation of muscle contraction; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; sarcomere organization; sequestering of calcium ion
Reference #:  O09161 (UniProtKB)
Alt. Names/Synonyms: AA033488; AW146219; calsequestrin 2; Calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardiac calsequestrin; Casq2; cCS; cCSQ; Csq; Csq2; ESTM5; ESTM52; MGC115896
Gene Symbols: Casq2
Molecular weight: 48,176 Da
Basal Isoelectric point: 4.09  Predict pI for various phosphorylation states
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calsequestrin 2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene