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GINS4
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. Belongs to the GINS4/SLD5 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 8p11.21 |
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Cellular Component:
CMG complex; cytoplasm; GINS complex; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; inner cell mass cell proliferation; positive regulation of DNA primase activity; positive regulation of DNA-directed DNA polymerase activity
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Reference #:
Q9BRT9
(UniProtKB)
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Alt. Names/Synonyms: DNA replication complex GINS protein SLD5; DNA replication complex GINS protein SLD5, N-terminally processed; GINS complex subunit 4; GINS complex subunit 4 (Sld5 homolog); GINS4; MGC14799; SLD5; SLD5 homolog
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Gene Symbols: GINS4
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Molecular weight:
26,047 Da
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Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
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