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CACNB2 iso2
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. Expressed in all tissues. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium |
| Chromosomal Location of human Ortholog: 10p12.33-p12.31 |
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Cellular Component:
L-type voltage-gated calcium channel complex; photoreceptor ribbon synapse; plasma membrane; presynapse; voltage-gated calcium channel complex
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Molecular Function:
actin filament binding; calcium channel activity; high voltage-gated calcium channel activity; protein binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
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Biological Process:
calcium ion import; calcium ion transmembrane transport; chemical synaptic transmission; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; neuromuscular junction development; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of calcium ion transport; positive regulation of high voltage-gated calcium channel activity; protein localization to plasma membrane; regulation of heart rate by cardiac conduction; regulation of presynaptic cytosolic calcium ion concentration; regulation of voltage-gated calcium channel activity; visual perception
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Reference #:
Q08289-2
(UniProtKB)
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Alt. Names/Synonyms: CAB2; CACB2; CACNB2; CACNB2 iso2; CACNLB2; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium voltage-gated channel auxiliary subunit beta 2; CAVB2; FLJ23743; Lambert-Eaton myasthenic syndrome antigen B; myasthenic (Lambert-Eaton) syndrome antigen B; MYSB; Voltage-dependent L-type calcium channel subunit beta-2
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Gene Symbols: CACNB2
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Molecular weight:
68,142 Da
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Basal Isoelectric point:
8.3
Predict pI for various phosphorylation states
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