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TNFAIP8L3
Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. Belongs to the TNFAIP8 family. Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044). Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 15q21.2 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; plasma membrane
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Molecular Function:
phosphatidylinositol binding; phosphatidylinositol transfer activity; protein binding
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Biological Process:
inositol lipid-mediated signaling; intermembrane lipid transfer; phospholipid metabolic process; phospholipid transport; positive regulation of ERK1 and ERK2 cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase B signaling; regulation of apoptotic process; regulation of lipid metabolic process
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Reference #:
Q5GJ75
(UniProtKB)
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Alt. Names/Synonyms: FLJ41287; TIPE3; TNF alpha induced protein 8 like 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3; TNFAIP8L3; TP8L3; Tumor necrosis factor alpha-induced protein 8-like protein 3; tumor necrosis factor, alpha induced protein 8 like 3; tumor necrosis factor, alpha-induced protein 8-like 3; tumor necrosis factor, alpha-induced protein 8-like protein 3
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Gene Symbols: TNFAIP8L3
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Molecular weight:
32,659 Da
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Basal Isoelectric point:
8.75
Predict pI for various phosphorylation states
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