TRH As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. Belongs to the TRH family. Hypothalamus. Expressed in the hair follicle epithelium (at protein level). Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component:  extracellular region
Biological Process:  adult walking behavior; cell-cell signaling; G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; negative regulation of feeding behavior; regulation of signaling receptor activity; response to cold; response to corticosterone; response to ethanol; response to glucose; response to hypoxia; signal transduction
Disease: Thyrotropin-releasing Hormone Deficiency
Reference #:  P20396 (UniProtKB)
Alt. Names/Synonyms: MGC125964; MGC125965; Pro-thyrotropin-releasing hormone; Pro-TRH; Prothyroliberin; Protirelin; Thyroliberin; thyrotropin releasing hormone; Thyrotropin-releasing factor; Thyrotropin-releasing hormone; TRF; TRH; TSH-releasing factor
Gene Symbols: TRH
Molecular weight: 27,404 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene