PROS1 Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Plasma. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 3q11.1
Cellular Component:  endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi lumen; Golgi membrane; plasma membrane; platelet alpha granule lumen
Molecular Function:  calcium ion binding; endopeptidase inhibitor activity
Biological Process:  blood coagulation; ER to Golgi vesicle-mediated transport; fibrinolysis; leukocyte migration; negative regulation of endopeptidase activity; platelet degranulation; regulation of complement activation
Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Dominant; Thrombophilia Due To Protein S Deficiency, Autosomal Recessive
Reference #:  P07225 (UniProtKB)
Alt. Names/Synonyms: PROS; PROS1; protein S; protein S (alpha); protein Sa; PS21; PS22; PS23; PS24; PS25; PSA; THPH5; THPH6; vitamin K-dependent plasma protein S; Vitamin K-dependent protein S
Gene Symbols: PROS1
Molecular weight: 75,123 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene