H4R The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Belongs to the G-protein coupled receptor 1 family. Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component:  plasma membrane
Molecular Function:  histamine receptor activity
Biological Process:  G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; regulation of MAPK cascade
Reference #:  Q9H3N8 (UniProtKB)
Alt. Names/Synonyms: AXOR35; BG26; G-protein coupled receptor 105; GPCR105; GPRv53; H4; H4R; HH4R; Histamine H4 receptor; histamine receptor H4; HRH4; MGC133027; Pfi-013; SP9144
Gene Symbols: HRH4
Molecular weight: 44,496 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB