DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. Belongs to the G-protein coupled receptor 1 family. Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 11p15.5
Cellular Component:  centrosome; dendrite; glutamatergic synapse; membrane; plasma membrane; postsynapse
Molecular Function:  dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; epinephrine binding; G protein-coupled serotonin receptor activity; identical protein binding; metal ion binding; neurotransmitter receptor activity; norepinephrine binding; potassium channel regulator activity; protein binding; SH3 domain binding
Biological Process:  adenylate cyclase-inhibiting dopamine receptor signaling pathway; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; chemical synaptic transmission; dopamine metabolic process; dopamine receptor signaling pathway; fear response; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; inhibitory postsynaptic potential; negative regulation of protein secretion; negative regulation of voltage-gated calcium channel activity; positive regulation of dopamine uptake involved in synaptic transmission; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of sodium:proton antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of postsynaptic neurotransmitter receptor internalization; response to amphetamine; response to histamine; rhythmic process; social behavior; synaptic transmission, dopaminergic
Disease: Attention Deficit-hyperactivity Disorder
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4; seven transmembrane helix receptor
Gene Symbols: DRD4
Molecular weight: 43,901 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB