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SET
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Belongs to the nucleosome assembly protein (NAP) family. Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit |
| Chromosomal Location of mouse Ortholog: 2|2 B |
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Cellular Component:
chromatin; cytoplasm; endoplasmic reticulum; lipid droplet; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
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Molecular Function:
chromatin binding; DNA binding; histone binding
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Biological Process:
negative regulation of neuron apoptotic process; nucleosome assembly
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Reference #:
Q9EQU5
(UniProtKB)
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Alt. Names/Synonyms: 2610030F17Rik; 5730420M11Rik; AA407739; I-2PP2A; MGC118419; OTTMUSP00000018110; Phosphatase 2A inhibitor I2PP2A; Protein SET; Set; SET nuclear oncogene; SET translocation; StF-IT; StF-IT-1; TAF-I; Template-activating factor I
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Gene Symbols: Set
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Molecular weight:
33,378 Da
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Basal Isoelectric point:
4.22
Predict pI for various phosphorylation states
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