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RMI2
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Belongs to the RMI2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication |
| Chromosomal Location of human Ortholog: 16p13.13 |
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Cellular Component:
cytosol; nuclear speck; nucleoplasm; nucleus; RecQ family helicase-topoisomerase III complex
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Molecular Function:
DNA binding; protein binding
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Biological Process:
DNA repair; DNA replication; double-strand break repair via homologous recombination; maintenance of rDNA; negative regulation of double-strand break repair via homologous recombination; regulation of sister chromatid segregation; resolution of recombination intermediates
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Reference #:
Q96E14
(UniProtKB)
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Alt. Names/Synonyms: BLAP18; BLM-associated protein of 18 kDa; C16orf75; chromosome 16 open reading frame 75; hRMI2; MGC24665; RecQ mediated genome instability 2; RecQ-mediated genome instability 2, S. cerevisiae, homolog of; RecQ-mediated genome instability protein 2; RMI2; RMI2, RecQ mediated genome instability 2, homolog
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Gene Symbols: RMI2
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Molecular weight:
15,865 Da
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Basal Isoelectric point:
7.76
Predict pI for various phosphorylation states
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