SLC17A4 Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  integral component of membrane; integral component of plasma membrane; lysosome; membrane; plasma membrane
Molecular Function:  sialic acid transmembrane transporter activity; symporter activity
Biological Process:  ion transport; sialic acid transport; sodium ion transport; transmembrane transport
Reference #:  Q5NCM1 (UniProtKB)
Alt. Names/Synonyms: 9130214H05Rik; Probable small intestine urate exporter; Putative small intestine sodium-dependent phosphate transport protein; S17A4; Slc17a4; solute carrier family 17 (sodium phosphate), member 4; Solute carrier family 17 member 4
Gene Symbols: Slc17a4
Molecular weight: 53,668 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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SLC17A4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene