5-HT(1D)
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. Belongs to the G-protein coupled receptor 1 family. Detected in brain neocortex and caudate nucleus (at protein level). Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of human Ortholog: 1p36.12 |
Cellular Component:
dendrite; plasma membrane; synapse
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Molecular Function:
G protein-coupled serotonin receptor activity; neurotransmitter receptor activity
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting serotonin receptor signaling pathway; chemical synaptic transmission; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; intestine smooth muscle contraction; regulation of behavior; regulation of locomotion; vasoconstriction
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Reference #:
P28221
(UniProtKB)
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Alt. Names/Synonyms: 5-HT(1D); 5-HT-1D; 5-HT-1D-alpha; 5-HT1D; 5-hydroxytryptamine (serotonin) receptor 1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; 5-hydroxytryptamine receptor 1D; 5HT1D; HT1DA; HTR1D; HTR1DA; HTRL; RDC4; Serotonin 1D alpha receptor; Serotonin receptor 1D
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Gene Symbols: HTR1D
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Molecular weight:
41,907 Da
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Basal Isoelectric point:
9.03
Predict pI for various phosphorylation states
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