G-alpha(z) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope
Chromosomal Location of mouse Ortholog: 10 C1|10 38.48 cM
Cellular Component:  cell body; dendrite; heterotrimeric G-protein complex; membrane; plasma membrane
Molecular Function:  adenylate cyclase inhibitor activity; G protein-coupled receptor binding; G protein-coupled serotonin receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway; negative regulation of insulin secretion; signal transduction
Reference #:  O70443 (UniProtKB)
Alt. Names/Synonyms: AI847979; G(x) alpha chain; G-alpha(z); Gnaz; guanine nucleotide binding protein, alpha z subunit; Guanine nucleotide-binding protein G(z) subunit alpha; Gz; Gz-alpha
Gene Symbols: Gnaz
Molecular weight: 40,850 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein